pentobarbital will reduce the level or effect of larotrectinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will reduce the extent or effect of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Reduced AUC of tramadol as well as Lively metabolite (O-desmethyltramadol) when coad